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JCRB Cell Bank cml cell lines kcl22
Cml Cell Lines Kcl22, supplied by JCRB Cell Bank, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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Article Title: Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia.
Article Snippet: The CML cell lines K562 and KCL22 were purchased from the Japanese Collection of Research Bioresources Cell Bank (JCRB, Ibaraki, Osaka, Japan), and BV173 was purchased from DSMZ (Braunschweig, Germany).



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Calculated LogP and anti-proliferation activities of alkynyl analogs

Journal: ChemMedChem

Article Title: Alkynylnicotinamide-based compounds as ABL1 inhibitors with potent activities against drug-resistant CML harboring ABL1(T315I) mutant kinase.

doi: 10.1002/cmdc.201700829

Figure Lengend Snippet: Calculated LogP and anti-proliferation activities of alkynyl analogs

Article Snippet: Evaluation of compounds activity against ABL1 and ABL1(T315I) inside CML cell lines KCL22 and KCL22-IR (by KinaSense, West Lafayette, IN, USA).

Techniques:

Inhibition of cellular ABL1 activity by imatinib, ponatinib and HSN compounds

Journal: ChemMedChem

Article Title: Alkynylnicotinamide-based compounds as ABL1 inhibitors with potent activities against drug-resistant CML harboring ABL1(T315I) mutant kinase.

doi: 10.1002/cmdc.201700829

Figure Lengend Snippet: Inhibition of cellular ABL1 activity by imatinib, ponatinib and HSN compounds

Article Snippet: Evaluation of compounds activity against ABL1 and ABL1(T315I) inside CML cell lines KCL22 and KCL22-IR (by KinaSense, West Lafayette, IN, USA).

Techniques: Inhibition, Activity Assay